Fascinating History of Acemannan, the Aloe Plant Extract

Dr. Reg MacDaniel MD is the international expert on the wide ranging health benefits of Acemannan, an extract of the Aloe Vera Plant. In this interview with Dr. Reg, the wide scope of Aloe Acemannan research over the past 40 years is previewed.

Visit the replay link below of a presentation by Kari Skinner who discusses the healing properties of Acemannan. Her focus is on how this extract in particular offers the potential to help persons currently confronting neurological symptoms.

Aloe has Magical Properties of Healing

I recommend this natural treatment option for Parkinsons be given serious consideration. It supports the ability of the body to heal rather than simply suppressing symptoms with medicines and supplements for the rest of a person’s life.

For more information visit: alovea.com

Validation of Aloe Acemannan Bioactivity by Independent Researchers and Publications:

1.Annual Reviews of Biochemistry 1985 Vol 54 ,R. Kornfeld, S Kornfeld.  Confirmed the fact that Carrington research for acetylated mannose (Acemannan) was bioactive compound in aloe leaf gel. 9 molecules in ER and Golgi form a domain on all cells in all organs for homeostasis. Probable scope for Acemannan benefits.determied  by this

2.Journal of Alzheimer’s Disease 2013, J.E. Lewis et.al. University of Miami Miller School of Medicine. 69% of patients received improved memory and cognition with no toxicity. CDc-14 stem cells increased, and Brain neurotrophic factor elevated as mechanism of action. Highest level of evidence-based science attained.

3.Carbohydrate Polymers, Vol, 291, 2022, Xueli Tong, et.al. China Research Team. Aloe Acemannan has anti-cancer properties against colon cancer cells. Mitochondria produce caspase that destroys cancer cell protein and causes no harm to normal cells. A historic event. Cancer research sought this property and failed.

4. Journal of Drug Delivery Science and Technology, Vol. 60, 2020, Khursheed Ali, et. Al. Saudis Arabia Research Team. Aloe Acemannan has anti-cancer properties against breast cancer cells, Mitochondria release caspase 3 and 9, with p-53and bax gene products. Identical MOAs are in China and Saudia Arabia.

5. Solvay International Research producer of chick vaccine that mimics how a human immune system will respond.  Over a million chicks in 10 broiler companies increased viral protection of flock from 60-65% to over 98% by adding a trace of Acemannan. Marek’s virus causing  T-cell lymphoma was eliminated. This is the top cause of loss in broiler industry. Chicks gained more weight on less chow. Human DPT potential is vast in why chicks gained weight on less chow.

6.Fisher Proceedings Vol.3, 2003.  A. Yisrael & M. Morris. Children rejected by state education system as public housing home failures with no academic future improved attitudes and class performance in church academy when a child’s Acemannan formulation was added to diet. Parents began support of education.

7.RFK Jr. Testimony to Congress made into a treatment pamphlet, Chapter 5, Statin drugs assailed for reducing cholesterol but not reducing strokes or cardiac attacks. Israel study in 2000 found that angina was eliminated and atheroma deposits in arteries reduced 30% by drinking pomegranate juice daily for a year.Aloe acemannanhas synergic property for allmolecules in indviduals.

Why

8. Nation Geographic Society Research identified 9 BLUE ZONES where plant-based diets and daily exercise resulted in better health and longevity, Acemannan is combined with numerous plant ingredients and provides a basis for health benefits of BLUE ZONES exist.

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9.International Immunopharmacology, Vol 5, 2005, Sun A. Im, et. al   All Acemannan powders do not have the same bioactivity due to processing methods.  The top 5 marketed Acemannans were assayed for molecular weight distribution ranges.  Lorand Laboratories Acemannan excelled at 18 & 22%, 400,000 Daltons and below molecular weight that maximally activates macrophages and the immune system. This is why we use Lorand Labs for superior bioactivity.

10. Australian Center for Complementary Medicine, Report Survey on 2400 Annual Dietary Supplement attendees taking primarily an aloe Acemannan formulation.  29 diseases and degrees of benefit are presented and a list of 47 symptoms with app. 1900 responses and amount of effectiveness are provided.

11,Molecular Biothermy.Vol 3,1991,University of Alabama and Southern Research Inst,, J. Kahlon, et.al.

RNA Interference Mechanism inactivated HIV-1 (AIDS) and Herpes Zoster viruses. FDA drug synergism reported. A genomic RNA audit rejects amino acid transformaion of foreign viral protein synthesis.

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12.Fisher Proceeding, Vol.4,2000,Loma Linda School of Medicine, Pediatric Dept. S. Risen,et.al.

Standard Asthma Treatment Combined with Glyco and Phyto Nutrients. Patients showed respiratory improvements at 3months and sustained in 6 months. Exercise tolerance, drug used benefitted.

   13. Fisher Proceedings Vol.  ,2000. Myesthenia Gravis study 80% off all drugs in 12 months.

14. China paper called the Aloe Acemannan Bible. Carrington research from 1980s & 90s is cited and further research performed.  Bone growth of face and regeneration of pulp in abscessed teeth is presented. Bibliography of multiple studies in foreign institutions are listed. Greatest source on aloe acemannan present.in all literature.

15. Fisher nstitute for Medical Research-syllabus.2002.by H.R. McDaniel. Intelligence Quotients (IQs) for 7  Fetal Alcohol  Syndrome (FAS) were <50. Retested following rapid  improvements and I Qs spanned from 80 to over 100. Foster parents had added Acemannan child’s formula to diets. How generation of millions of stem cells was developed and recognized.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
Road to Recovery from Parkinsons Disease

Redox Signaling Molecules

I am guessing you have likely never heard about redox signaling molecules. A search on the depository of medical publications (pubmed.gov) reveals that more than 400 studies have been published in the first six months of 2026 alone. Over 7,300 studies have been published overall. This is a recent discovery that has attracted the interest of hundreds of researchers across the globe. I want you to know more about it too!

As is evident from my presentation above, I am excited about the potential for redox signaling molecules to offer welcome relief from neurological challenges.

Get all of your questions answered in several ways. First, visit https://www.recoverwithredox.net. Complete the contact form and a representative from the company will contact you to answer all of your questions.

Second watch this marvelous presentation on redox signaling by Alan Noble who really is the first person who recognized the value of this technology to bring the body back into balance and harmony.

Third, watch this short 6 minute youtube video that demonstrates how redox signaling has a quick impact on reducing inflammation in the brain.

What success have users had from using redox signaling? A website offers interviews with individuals who report positive experiences. Visit: realredoxresults.com. Enter the password redox for access to the interviews.

In summary, I recommend you take this option under serious consideration. It has clearly helped many people and offers the opportunity to help you too.

Robert

Get the Support You Need to Manifest Recovery

I have been working intensively with members to help them evaluate and implement natural therapies. Results have been encouraging indeed. No one yet has fully recovered, but many are making excellent progress on their journey down the road to recovery.

I am now filling out my calendar for the rest of the year. I would consider it a high honor to help support your recovery.

This is the last call to register for my 1 on 1 mentoring program for us to explore the options that will help reverse your symptoms.

Visit the link below for more information about the opportunity to recruit my ongoing help and support for your recovery:

Manifest Recovery Now
The 50% coupon code succeed expires the end of July (which is today!)

Robert Rodgers, Ph.D.

Redox Gold

Do you experience pain or restrictions in muscles that derail your ability to walk effortlessly?

I have a recommendation for you to consider that offers the opportunity to celebrate relief from pain and restrictions in various muscles whether they be your feet, legs, back or shoulders.

Redox gold is a recent discovery formulated from – get this – gold and the ground breaking redox technology. It is a topical application that can be applied to a specific source of pain or restriction that affects mobility. Best of all – results are celebrated within minutes after application. 

The youtube video below offers a scientific explanation of redox gold.   

Redox Gold

Below is an explanation by Alan Noble of the science behind redox signaling molecules offer healing from the inside out. 

I have applied to Redox Gold to a lower back pain which offered relief within minutes. You will know whether it helps you reduce discomfort and improve mobility. No need to wait months to determine if something offers relief from symptoms. 

Robert 

Redox Signaling – a Revolutionary Discovery

Researchers have only recently recognized the central role redox signaling plays to support the health of humans, plants and animals. It is the boost needed to reverse illness and sustain health.

For further information about ASEA and order information visit:
https://www.recoverwithredox.net

Redox signaling supports the ability of cells to respond appropriately to environmental stimuli. When each cell acts independently of other cells, its ability to avert illness and disease is compromised. Redox cell signaling activates communication among cells to support the body’s ability to reverse illness and sustain wellness.

Studies report that redox cell signaling …

  • Does no harm
  • Contains no toxins
  • Wakes up sleepy cells
  • Helps un-poison the body
  • Activates a natural process of healing
  • Has anti-viral properties
  • Addresses bacterial infections
  • Facilitates the production of glutathione by the body
  • Reduces reactions to chronic stress

When confronted with neurological challenges, the allostatic load becomes too great for the body to perform the functions of toxic elimination. All of the body’s elimination organs (eg: liver, kidneys, colon, skin) are confronted with getting rid of more toxins than can be processed out of the body at any given time. The problem is analogous to when a dam overflows.

As the body becomes less able to eliminate the toxins that have accumulated the overflow overwhelms the body’s ability to function. This compromises the natural ability of the body to rejuvenate and regenerate. With Parkinsons, the allostatic load becomes too overwhelming for the body to perform the functions of elimination and renewal.

Redox signaling helps reduce an allostatic load that has maxed out.

For further information about ASEA and order information visit:
https://www.recoverwithredox.net

Research on Redox Signaling and Parkinsons

Researchers are clearly enthused about the prospects for redox signaling molecules. A search on the Pubmed.gov research platform lists 7,262 studies that have been published when searching the terms “redox signaling molecules”. The explosive interest in this topic indicates it merits serious consideration.

Chin Med J (Engl). 2026 Mar 5;139(5):653–671. Role of LRRK2 in physiological activities, diseases, and therapy

Abstract

Leucine-rich repeat kinase 2 (LRRK2) is a critical target for the treatment of Parkinson’s disease (PD) and potentially other diseases. LRRK2 is involved in intracellular signaling, immune response, and inflammation, with key roles in both the central nervous system and peripheral tissues.

LRRK2 mutations are linked to cellular dysfunction including mitochondrial and neuronal damage and can disrupt signaling pathway balance, thereby contributing to PD and other disorders

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery ®

Mentoring with Robert

I have an opening for only more individual which I have reserved for members. I am elated to report that the members I have been connecting with every two weeks are getting better.

On this day I extend a warm invitation for you to join my one on one consulting/mentoring program. Imagine how differently you will feel after working together with me as we fit together the pieces of a successful recovery program.

Introducing my One on One  Mentorship Program – Your Personal Roadmap to Recovery from neurological challenges. To enroll in the program click on the registration link below. Enter the coupon code succeed to claim the 50% member discount today.

One on One Mentoring with Robert

My mentoring program is all about having the right plan of recovery customized specifically for your unique situation as you celebrate relief from Parkinsons with natural therapies and methods.

What is Included

1. Initial strategy session with me personally to flesh out the potential causes of your symptoms so we can identify therapies and treatments that can successfully address them. This is not some surface-level consultation. It is a deep dive into your specific history and situation. We evaluate what you have tried that did not succeed and what did help. We consider new options.  

2. Together we lay out a custom-crafted program of recovery created specifically for your situation.

3. With bimonthly hourly meetings (with a video type interface similar to Zoom or telephone/email contact), we review, update and revise your program of recovery. 

  • We review your progress since our last session
  • Identify and solve any roadblocks you have confronted.
  • Refine the recovery program based on real-world results documented by research
  • Help keep you on track with your program of recovery
  • Support your progress with new therapeutic and treatment options

4. Unlimited email access to me personally

Why Do I Offer One on One Mentoring

First – After nearly 22 years of researching the causes of Parkinsons and the natural therapies that can reverse them,  I have reached a point where my greatest satisfaction in life comes from seeing more and more individuals transform their health.

Second – The individuals I have been mentoring over recent months have been making remarkable progress. This warms my heart and soothes my soul to know that the ongoing attention and support is making a difference.

For more information and to register click on the link below.
One on One Mentoring with Robert

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery®
https://www.parkinsonsrecovery.com

Studies Report Acemannan, an Extract from the Aloe Plant, offers Relief from Troublesome Symptoms

Interested in learning about a natural way to support your body’s ability to target the cause of symptoms that has no side effects and is based on research?

If the answer is yes, watch the replay of the Kari Skinner’s awesome presentation on Acemannan and also about an extract from beets that also is beneficial for Parkinsons. Here is the zoom link to watch:

https://us02web.zoom.us/rec/share/44JpdsNKAUJUbeD2-AfuDVfxvYuuL0sHXKoOEDQskwS_UV6IIdfbSE9FXcopmVQ7.3GaTV1bQ358DBBQB?startTime=1775761272000

I have received a surprising number of unsolicited comments from members of my audience who have offered high praise for Kari’s presentation. You will not be disappointed.

Robert

Photobiomodulation Studies Published in 2025

Seven years ago there were no studies that evaluated photobiomodulation as a treatment for Parkinsons. Since that time the research has exploded.

Selected below are listings of 2025 studies that focus on photobiomodulation as a treatment for Parkinsons. All five studies conclude it is a viable in home, non invasive therapy that offers the opportunity of symptom relief.

The positive experiences of persons in my audience who use photobiomodulation combined with the research evidence leads me to recommend photobiomodulation as a natural, safe therapy for Parkinsons.

The gold standard company that has invented photobiomodulation devices that are in use by members of the Parkinsons Recovery® audience is Vielight.com. They now have published 25 studies using their devices.

The device used in the Vielight.com Parkinsons studies is the Neuro Gamma which is available at a 10% discount when using the coupon code healing4me.
The company offers an 80% refund when any device is returned after six months of use. I might add that when you call the company – you connect with a human being who will patiently answer all of your questions. You will not be talking with AI.

Ninety percent (90%) of users in my audience have kept their device. Only 10% return a device to claim the 80% refund. The risk associated with the Vielight option is minimal when contrasted with the expected benefits.

The mission of Parkinsons Recovery is to support the recovery of more and more persons diagnosed with Parkinsons. The Vieight photobiomodulation devices are helping to manifest this mission.

Photobiomodulation Parkinsons Studies

Lasers Med Sci. 2025 Oct 20;40(1):441. Posture stability and functional activity changes after transcranial photobiomodulation for patients with Parkinson’s disease: A randomized controlled trial

Abstract

Background: Parkinson’s disease (PD) is an incapacitating progressive neurological disorder that exerts a significant effect on quality of life. There is no cure, so current treatments aim to decrease symptoms due to central nervous system dopamine deficiency.

Purpose: The study was to monitor how transcranial photobiomodulation (tPBM) improved patients with Parkinson’s disease.

Methods: A randomized controlled trial study, where thirty-eight patients of both genders, aged 50-70 years, suffering from postural instability and limited functional activity level due to PD, were randomly assigned to two groups: group A of the experimental group was treated with transcranial photobiomodulation (tPBM), and group B of the control group was provided with standard treatment. All the assessments were conducted before and after the 12-week treatment schedule.

Results: Statistically significant differences in limit of stability and functional level of the experimental group were observed in favor after 3 months of training (P < 0.05).

Conclusion: tPBM might be effective in improving posture stability and functional activity level of Parkinson’s disease patients

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J Clin Med. 2025 Oct 22;14(21):7463. Effectiveness of Photobiomodulation to Treat Motor and Non-Motor Symptoms of Parkinson’s Disease: A Randomized Clinical Trial with Extended Treatment

Abstract

Background/Objective: Few treatment options improve symptoms and the quality of life of Parkinson’s disease (PD); more treatment choices are needed. This study examined the effectiveness of photobiomodulation therapy (PBMt) combined with exercise to improve PD symptoms and quality of life. 

Methods: Participants were randomised into Active (n = 32) or Sham (n = 31) PBMt groups. Stage 1 was an 8-week double-blind, randomized, placebo-controlled trial using either active or sham PBMt to the head, back of the neck and abdomen three times weekly at home, followed by a 4-week washout. Stage 2 was 8 weeks of active PBMt for all participants. In Stage 3, participants chose to continue active PBMt treatment (‘continuers’) or receive no PBMt treatment (‘non-continuers’) for up to 48 weeks. Participants continued vigorous exercise throughout the study. Participants were assessed on enrolment and after each stage. The primary outcome measure was timed up-and-go, with a range of secondary motor and non-motor outcomes, including UPDRS. 

Results: There was no significant difference between the Active and Sham Groups after Stages 1 or 2, apart from minimal increase in MoCA score/cognition (Sham Group) in Stage 1. After Stage 3, continuers showed a significant improvement in the primary outcome measure compared to non-continuers. Anxiety and the motor experiences of daily living (MDS-UPDRS Part II) were also significantly improved, while other outcomes approached significance, including MDS-UPDRS Total score (p = 0.062). 

Conclusions: As the largest study to date, results add increasing weight to previous clinical trials and highlight potential for at-home, scalable treatment as adjunctive therapy alongside medication and exercise.

J Clin Med. 2026 Jan 4;15(1):368. Five-Year Follow-Up of Photobiomodulation in Parkinson’s Disease: A Case Series Exploring Clinical Stability and Microbiome Modulation

Abstract

Background: Parkinson’s disease (PD) involves neurodegeneration with clinical or subclinical disturbance of the gut-brain axis, including altered gastrointestinal motility and enteric nervous system involvement. Clinical studies have reported gut microbiome alterations in PD, with shifts in taxa associated with inflammatory signalling and short-chain fatty acid (SCFA) metabolism.

Photobiomodulation (PBM), a non-invasive light therapy, has been investigated as a potential adjunctive treatment for PD, with proposed effects on neural, metabolic, and immune pathways. We previously reported the five-year clinical outcomes in a PBM-treated Parkinson’s disease case series. Here we report the five-year gut microbiome outcomes based on longitudinal samples collected from the same participants. This was an exploratory, open-label longitudinal study without a control group. 

Objective: Our objective was to assess whether long-term PBM was associated with changes in gut microbiome diversity and composition in the same Parkinson’s disease cohort as previously assessed for changes in Parkinson’s symptoms. 

Methods: Six participants from the earlier PBM proof-of-concept study who had been diagnosed with idiopathic PD and who had continued treatment (transcranial light emitting diode [LED] plus abdominal and neck laser) for five years had their fecal samples analyzed by 16S rDNA sequencing to assess microbiome diversity and taxonomic composition. 

Results: Microbiome analysis revealed significantly reduced evenness and significant shifts in diversity over five years, as assessed by Permutational Multivariate Analysis of Variance (PERMANOVA). At the phylum level, Pseudomonadota and Methanobacteriota decreased in four of the six participants. Both of these phyla are often increased in the Parkinson’s microbiome compared with the microbiomes of healthy controls. Family-level changes included increased acetate-producing Bifidobacteriaceae (five of the six participants); decreased pro-inflammatory, lipopolysaccharide (LPS)-producing Enterobacteriaceae (two of the three participants who have this bacterial family present); and decreased LPS- and H2S-producing Desulfovibrionaceae (five of six). At the genus level, Faecalibacterium, a key butyrate producer, increased in four of the six participants, potentially leading to more SCFA availability, although other SCFA-producing bacteria were decreased. This was accompanied by reductions in pro-inflammatory LPS and H2S-producing genera that are often increased in the Parkinson’s microbiome. 

Conclusions: This five-year case series represents the longest follow-up of microbiome changes in Parkinson’s disease. The parallel changes in improvements in mobility and non-motor Parkinson’s symptoms observed in this cohort raises the hypothesis that photobiomodulation may interact with the gut-brain axis via the microbiome.

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Geroscience. 2025 Jun;47(3):2777-2789. Light buckets and laser beams: mechanisms and applications of photobiomodulation (PBM) therapy

Abstract

Photobiomodulation (PBM) therapy, a non-thermal light therapy using nonionizing light sources, has shown therapeutic potential across diverse biological processes, including aging and age-associated diseases.

In 2023, scientists from the National Institute on Aging (NIA) Intramural and Extramural programs convened a workshop on the topic of PBM to discuss various proposed mechanisms of PBM action, including the stimulation of mitochondrial cytochrome C oxidase, modulation of cell membrane transporters and receptors, and the activation of transforming growth factor-?1. They also reviewed potential therapeutic applications of PBM across a range of conditions, including cardiovascular disease, retinal disease, Parkinson’s disease, and cognitive impairment.

Workshop participants largely agreed that PBM holds immense potential as a safe and effective therapeutic approach for a wide range of age-related diseases and cognitive decline. The findings presented at the NIA workshop provide strong evidence for the continued investigation and clinical translation of this promising, inexpensive, safe technology, to aging and age-associated diseases.

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Photodiagnosis Photodyn Ther. 2025 Oct:55:104712. The role of photobiomodulation in modulating neural activity and brain function: A systematic bibliometric analysis

Abstract

This systematic bibliometric analysis evaluates the scientific evidence, impact, and trends of photobiomodulation (PBM) for central nervous system (CNS) disorders. Analyzing 150 relevant PubMed-indexed studies (including 46 clinical trials) up to September 2024, we demonstrate PBM’s positive effects on the CNS. Key mechanisms include enhanced ATP synthesis, modulated nitric oxide signaling, improved neuronal excitability, suppressed oxidative stress, anti-inflammatory effects, and ion channel modulation. PBM offers therapeutic flexibility: shorter-wavelength, high-irradiance power lasers effectively target deep brain structures, while both modalities suit superficial cortical applications where fine spatial control is nonessential.

Crucially, PBM induces long-lasting biological effects, highlighting significant potential for chronic CNS conditions like Alzheimer’s disease, Parkinson’s disease, and stroke.

Robert Rodgers PhD
Founder 2004
Parkinsons Recovery ®
https://www.parkinsonsrecovery.com

Consultations, Mentoring and Support from Me Still Available for Members

Let Me Be Your Mentor

Consultations Still Available for Members 

What has been most helpful to persons with Parkinsons who manifest successful recoveries is the opportunity for ongoing, one on one consultations, mentoring and support. 

The opportunity for consultations with me every two weeks is still available for members at the 75% discounted rate of $50 per session ($95 per month for three months). 

Visit the link below for more information about this limited opportunity.

2026 Mentoring

Robert Rodgers, Ph.D.